SCHEMBL1482827

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4233232	0.94	METAP1 (0.50)	METAP1ADORA2AROCK1L3MBTL1NPC1
	SCHEMBL4227691	0.89	METAP1 (0.49)	METAP1ADORA2AROCK1L3MBTL1NPC1
	SCHEMBL1497472	0.88	ROCK2 (0.39)	METAP1ROCK1ROCK2
	SCHEMBL1497457	0.87	PDCD1 (0.37)	METAP1ROCK1ROCK2
	SCHEMBL1497069	0.87	PDCD1 (0.36)	METAP1ROCK1ROCK2
	SCHEMBL1482715	0.86	ADORA2A (0.39)	METAP1ADORA2AROCK1L3MBTL1NPC1
	SCHEMBL1496961	0.86	PDCD1 (0.36)	METAP1ROCK1ROCK2
	SCHEMBL1497091	0.85	TRPA1 (0.38)	ROCK1ROCK2
	SCHEMBL1497118	0.85	NAMPT (0.45)	ROCK1NPC1RAB9AALDH1A1ROCK2
	SCHEMBL1496932	0.85	PDCD1 (0.37)	METAP1ROCK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.