Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12988780 | 1.00 | HSD11B1 (0.40) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL12988779 | 1.00 | HSD11B1 (0.40) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL21440281 | 0.86 | HTR2A (0.37) | HDAC8HDAC6HDAC3HTR2ALMNA | |
| SCHEMBL13250230 | 0.85 | HSD11B1 (0.43) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL14841787 | 0.84 | AGER (0.41) | HDAC8HDAC6HDAC3HDAC1HTR2A | |
| SCHEMBL12987671 | 0.82 | KDM1A (0.41) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL12987673 | 0.82 | KDM1A (0.41) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL14829217 | 0.82 | KDM1A (0.41) | HSD11B1NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL25609126 | 0.81 | HTR2A (0.46) | HSD11B1NR1H4HTR2ALMNA | |
| SCHEMBL14838596 | 0.79 | NR1H4 (0.41) | HSD11B1NR1H4HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3878851-A1 | PROCESS FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2021-09-15 | — | — | EP | disclosed |
| US-10822331-B2 | Processes for preparing ATR inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-11-03 | — | — | US | disclosed |
| EP-3608316-A1 | DEUTERATED DERIVATIVES OF AN INHIBITOR OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2020-02-12 | — | — | EP | disclosed |
| US-10435397-B2 | — | — | 2019-10-08 | — | — | US | disclosed |
| EP-2940017-B1 | Process for making compounds useful as inhibitors of ATR kinase | VERTEX PHARMA (US) | 2019-08-28 | — | — | EP | disclosed |
| US-20190202818-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2019-07-04 | — | — | US | disclosed |
| US-10208027-B2 | Processes for preparing ATR inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-02-19 | — | — | US | disclosed |
| US-20180244662-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2018-08-30 | — | — | US | disclosed |
| US-9862709-B2 | Processes for making compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-01-09 | — | — | US | disclosed |
| EP-2751099-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2940017-A2 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2015-11-04 | — | — | EP | disclosed |
| US-20150274710-A1 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2015-10-01 | — | — | US | disclosed |
| US-9035053-B2 | Processes for making compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-05-19 | — | — | US | disclosed |
| US-8846686-B2 | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2751097-A2 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-2751099-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2014-07-09 | — | — | EP | disclosed |
| US-20130184292-A1 | Processes for Making Compounds Useful as Inhibitors of ATR Kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130089625-A1 | Compounds Useful as Inhibitors of ATR Kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2013049726-A2 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013049722-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822331-B2 | Processes for preparing ATR inhibitors | ATR, ATRIP, CHEK1 | HSD11B1 2481/4885NR1H4 4703/4885HDAC8 2193/4885 |
| US-20130184292-A1 | Processes for Making Compounds Useful as Inhibitors of ATR Kinase | ATR, ATRIP, CHEK1 | HSD11B1 2670/4885NR1H4 4694/4885HDAC8 2207/4885 |
| US-20190202818-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | ATR, ATRIP, CHEK1 | HSD11B1 2307/4885NR1H4 4740/4885HDAC8 2190/4885 |
| US-10435397-B2 | — | ATR, ATRIP, TBK1 | HSD11B1 2802/4885NR1H4 4470/4885HDAC8 1890/4885 |
| US-20150274710-A1 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, ATRIP, CHEK1 | HSD11B1 2670/4885NR1H4 4694/4885HDAC8 2207/4885 |
| US-20130089625-A1 | Compounds Useful as Inhibitors of ATR Kinase | ATR, CHEK1, MAP3K1 | HSD11B1 2912/4885NR1H4 4614/4885HDAC8 1507/4885 |
| US-20180244662-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | ATR, ATRIP, CHEK1 | HSD11B1 2307/4885NR1H4 4740/4885HDAC8 2190/4885 |
| US-10208027-B2 | Processes for preparing ATR inhibitors | ATR, ATRIP, CHEK1 | HSD11B1 2307/4885NR1H4 4740/4885HDAC8 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.