Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14829280 | 0.71 | ALDH1A1 (0.38) | KDM4EL3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL14846543 | 0.68 | MAPT (0.38) | KDM4EL3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL4829568 | 0.67 | CA12 (0.50) | L3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL29158848 | 0.66 | GCGR (0.65) | KDM4EL3MBTL1ALDH1A1MAPTNPSR1 | |
| SCHEMBL30741073 | 0.66 | PDE3B (0.56) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL8165963 | 0.65 | PTGDR2 (0.41) | KDM4EALDH1A1HPGDRXRARXRB | |
| SCHEMBL31747940 | 0.65 | RXRA (0.38) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL1156279 | 0.63 | KMT2A (0.67) | KDM4EL3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL25292403 | 0.63 | ALDH1A1 (0.42) | KDM4EL3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL31048564 | 0.63 | ALDH1A1 (0.42) | KDM4EL3MBTL1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760839-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049104-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |