Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14846543 | 0.72 | MAPT (0.38) | ALDH1A1KDM4EL3MBTL1KMT2ARXRA | |
| SCHEMBL14829281 | 0.71 | KDM4E (0.39) | ALDH1A1KDM4EL3MBTL1KMT2ARXRA | |
| SCHEMBL4829568 | 0.68 | CA12 (0.50) | ALDH1A1L3MBTL1KMT2AMAPT | |
| SCHEMBL25292403 | 0.68 | ALDH1A1 (0.42) | ALDH1A1KDM4EL3MBTL1KMT2ARXRA | |
| SCHEMBL31048564 | 0.68 | ALDH1A1 (0.42) | ALDH1A1KDM4EL3MBTL1KMT2ARXRA | |
| SCHEMBL8493149 | 0.64 | GABRP (0.56) | ALDH1A1KDM4EL3MBTL1KMT2AHPGD | |
| SCHEMBL29777 | 0.64 | MAPT (0.48) | ALDH1A1KDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL30091622 | 0.64 | GPR52 (0.39) | ALDH1A1KDM4EL3MBTL1KMT2AHPGD | |
| SCHEMBL23927471 | 0.64 | GPR52 (0.39) | ALDH1A1KDM4EL3MBTL1KMT2AHPGD | |
| SCHEMBL1085616 | 0.63 | ALDH1A1 (0.51) | ALDH1A1KDM4EL3MBTL1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760839-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049104-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |