Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 5/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14829870 | 0.88 | SLC6A4 (0.38) | SLC6A4ARACHEKDM4EMEN1 | |
| SCHEMBL14829948 | 0.73 | LIPG (0.46) | KDM4EMEN1KMT2AMAPTRXFP1 | |
| SCHEMBL16632927 | 0.67 | ALDH1A1 (0.47) | ARKDM4EMEN1KMT2AMAPT | |
| SCHEMBL14848288 | 0.66 | LIPG (0.47) | KDM4ETP53MAPTALDH1A1 | |
| SCHEMBL15978949 | 0.64 | LIPG (0.48) | KDM4EMEN1KMT2ATP53MAPT | |
| SCHEMBL15970555 | 0.62 | LIPG (0.44) | KDM4EMEN1KMT2A | |
| SCHEMBL14318120 | 0.58 | ALDH1A1 (0.58) | ACHEKDM4EMEN1KMT2AMAPT | |
| SCHEMBL1043968 | 0.57 | HDAC1 (0.51) | ARKDM4EMEN1KMT2APOLQ | |
| SCHEMBL3715319 | 0.57 | EGFR (0.44) | ARKDM4EKMT2ADAOALDH1A1 | |
| SCHEMBL12016034 | 0.57 | IDO1 (0.49) | SLC6A4KDM4EMEN1KMT2APOLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760840-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048942-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |