Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | DDO | Q99489 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31146189 | 0.79 | DYRK1A (0.38) | EGFRKDM4ELMNAPARP1KMT2A | |
| SCHEMBL3716515 | 0.76 | KDM4E (0.40) | KDM4ELMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL8306652 | 0.75 | KDM4E (0.59) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL24190146 | 0.74 | ABL1 (0.46) | KDM4EHSD17B10KMT2ANR3C1ALDH1A1 | |
| SCHEMBL30396884 | 0.74 | ABL1 (0.46) | KDM4EHSD17B10KMT2ANR3C1ALDH1A1 | |
| SCHEMBL3359175 | 0.73 | DAO (0.64) | KDM4ELMNAKMT2ADAODDO | |
| SCHEMBL871601 | 0.72 | POLQ (0.55) | KDM4EALDH1A1 | |
| SCHEMBL30474543 | 0.72 | POLQ (0.55) | KDM4EALDH1A1 | |
| SCHEMBL31645683 | 0.72 | P2RX7 (0.47) | KDM4E | |
| SCHEMBL31146101 | 0.72 | EGFR (0.40) | EGFRKDM4ELMNAHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393806-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | Elan Pharmaceuticals Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091310-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |