SCHEMBL14830588

SCHEMBL14830588

CCCCOC(=O)N1CC[C@H]([C@@H](CS(C)(=O)=O)Oc2ccc(C(F)(F)F)cc2)C1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 3/20 0.40
MMP3 P08254 2/20 0.40
MMP9 P14780 2/20 0.40
MMP2 P08253 1/20 0.40
MMP8 P22894 1/20 0.40
CHRM2 P08172 1/20 0.38
CHRM1 P11229 1/20 0.38
LIPC P11150 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
TRPC3 Q13507 1/20 0.37
TRPC7 Q9HCX4 1/20 0.37
P2RY12 Q9H244 4/20 0.37
MCHR1 Q99705 2/20 0.37
LIPE Q05469 1/20 0.36
GPR119 Q8TDV5 1/20 0.36
MMP1 P03956 1/20 0.36
MMP7 P09237 1/20 0.36
EPHX2 P34913 1/20 0.36
SLC6A5 Q9Y345 1/20 0.36
SLC6A4 P31645 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9281151 0.89 LIPC (0.39) MMP13MMP3MMP9MMP2MMP8
SCHEMBL9280632 0.87 LIPC (0.40) MMP13MMP3MMP9MMP2MMP8
SCHEMBL1689452 0.87 MMP13 (0.46) MMP13MMP3MMP9MMP2MMP8
SCHEMBL14813406 0.87 MMP13 (0.46) MMP13MMP3MMP9MMP2MMP8
SCHEMBL9108738 0.79 MMP13 (0.46) MMP13MMP3MMP9MMP2MMP8
SCHEMBL9108746 0.79 MMP13 (0.46) MMP13MMP3MMP9MMP2MMP8
SCHEMBL9108211 0.75 MMP13 (0.45) MMP13LIPEGPR119EPHX2
SCHEMBL9108220 0.75 MMP13 (0.45) MMP13LIPEGPR119EPHX2
SCHEMBL9110045 0.74 DPP4 (0.45) MMP13GPR119EPHX2
SCHEMBL9110055 0.74 DPP4 (0.45) MMP13GPR119EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2760826-A1 CRYSTALLINE FORMS OF A 3-[2-METHANESULFONYL-1-(4-TRIFLUOROMETHYL-PHENOXY)ETHYL]PYRROLIDINE COMPOUND Theravance, Inc. (US) 2014-08-06 EP claimed
WO-2013049617-A1 CRYSTALLINE FORMS OF A 3-[2-METHANESULFONYL-1-(4-TRIFLUOROMETHYL-PHENOXY)ETHYL]PYRROLIDINE COMPOUND THERAVANCE, INC. (US) 2013-04-04 WO claimed