Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 12/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.46 |
| ▸ | RHOC | P08134 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815112 | 1.00 | MEN1 (0.53) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14815335 | 0.96 | MGLL (0.54) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14815069 | 0.92 | CCR2 (0.54) | MEN1KMT2ACCR2L3MBTL3L3MBTL1 | |
| SCHEMBL14833216 | 0.92 | CCR2 (0.54) | MEN1KMT2ACCR2L3MBTL3L3MBTL1 | |
| SCHEMBL14814550 | 0.91 | KMT2A (0.50) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14830396 | 0.91 | KMT2A (0.50) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14815072 | 0.90 | L3MBTL3 (0.55) | MEN1KMT2AMGLLL3MBTL3L3MBTL1 | |
| SCHEMBL14815167 | 0.89 | KMT2A (0.50) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14833493 | 0.89 | KMT2A (0.50) | MEN1KMT2AMGLLCCR2L3MBTL3 | |
| SCHEMBL14833315 | 0.89 | MEN1 (0.49) | MEN1KMT2AMGLLCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | claimed |
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |