Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14816151 | 1.00 | HTT (0.53) | HTTCNR1LMNAPKMPKLR | |
| SCHEMBL14816030 | 1.00 | HTT (0.53) | HTTCNR1LMNAPKMPKLR | |
| SCHEMBL14816195 | 0.89 | HSD11B1 (0.43) | HTTCNR1LMNAPKMPKLR | |
| SCHEMBL14816012 | 0.86 | TRPV4 (0.50) | LMNAALDH1A1GAAHSD11B1KDM4E | |
| SCHEMBL14816153 | 0.86 | TRPV4 (0.50) | LMNAALDH1A1GAAHSD11B1KDM4E | |
| SCHEMBL14816198 | 0.84 | CNR1 (0.42) | CNR1GAAL3MBTL1 | |
| SCHEMBL14815870 | 0.81 | TSHR (0.40) | LMNAPKMALDH1A1SMN1; SMN2HSD11B1 | |
| SCHEMBL14815765 | 0.81 | ALDH1A1 (0.42) | LMNAPKMUSP2ALDH1A1KMT2A | |
| SCHEMBL7951411 | 0.81 | CNR1 (0.58) | HTTCNR1LMNAPKMPKLR | |
| SCHEMBL7960720 | 0.81 | CNR1 (0.58) | HTTCNR1LMNAPKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049174-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-A]PYRAZINE SULFONAMIDES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |