Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 4/20 | 0.56 |
| ▸ | EIF4H | Q15056 | 4/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.45 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.45 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148606 | 0.94 | PABPC1 (0.65) | PABPC1EIF4HMAPTHDAC6MEN1 | |
| SCHEMBL149086 | 0.79 | MAPT (0.70) | MAPTHDAC6MEN1KMT2AL3MBTL1 | |
| SCHEMBL147834 | 0.77 | HTT (0.56) | MAPTPARP14MEN1KMT2AL3MBTL1 | |
| SCHEMBL148468 | 0.74 | ALDH1A1 (0.58) | PARP14MEN1KMT2AL3MBTL1HTT | |
| SCHEMBL7502761 | 0.73 | MEN1 (0.65) | PABPC1EIF4HMAPTMEN1KMT2A | |
| SCHEMBL27907641 | 0.73 | PBRM1 (0.53) | MAPTPARP14MEN1KMT2AJAK2 | |
| SCHEMBL27579461 | 0.72 | PLK4 (0.73) | PABPC1EIF4HPTPN1PTPN11HDAC6 | |
| SCHEMBL27583488 | 0.72 | PABPC1 (0.72) | PABPC1EIF4HMAPTHDAC6MEN1 | |
| SCHEMBL394478 | 0.71 | CFTR (0.61) | PABPC1EIF4HMAPTHDAC6MEN1 | |
| SCHEMBL1902196 | 0.71 | PTPN1 (0.67) | PABPC1EIF4HPTPN1PTPN11HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | PABPC1 4423/4885EIF4H 2375/4885PTPN1 502/4885 |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | PABPC1 4423/4885EIF4H 2375/4885PTPN1 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.