Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14835601 | 1.00 | EPHA2 (0.45) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL14835647 | 1.00 | EPHA2 (0.45) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL12527484 | 0.85 | KMT2A (0.43) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL8891747 | 0.82 | GPR119 (0.42) | EPHA2GPR119 | |
| SCHEMBL20913869 | 0.82 | GPR119 (0.42) | EPHA2GPR119 | |
| SCHEMBL18689807 | 0.82 | GPR119 (0.42) | EPHA2GPR119 | |
| SCHEMBL31494035 | 0.81 | EPHA2 (0.42) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL617822 | 0.79 | PDK1 (0.45) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL617821 | 0.79 | PDK1 (0.45) | EPHA2GPR119MMP1MMP9MMP3 | |
| SCHEMBL618014 | 0.79 | PDK1 (0.45) | EPHA2GPR119MMP1MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576510-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153509-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-08 | — | — | WO | disclosed |