SCHEMBL14837

SCHEMBL14837

CCCCc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCN(c4ccccc4OC)CC3)c2)cc1

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.62
MAPT P10636 3/20 0.62
ALDH1A1 P00352 2/20 0.62
HTT P42858 2/20 0.62
HCRTR1 O43613 1/20 0.55
LMNA P02545 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
REV1 Q9UBZ9 1/20 0.51
DRD2 P14416 1/20 0.50
HTR2A P28223 1/20 0.50
MAPK1 P28482 1/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18973824 0.89 ALDH1A1 (0.53) PKMALDH1A1HCRTR1LMNAL3MBTL1
SCHEMBL12035 0.88 PKM (0.69) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL12598472 0.87 METAP2 (0.58) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL12598471 0.87 ALDH1A1 (0.51) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL14802 0.87 PKM (0.60) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL12129 0.87 ALDH1A1 (0.69) PKMMAPTALDH1A1HTTLMNA
SCHEMBL19186636 0.87 KMT2A (0.51) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL1978698 0.86 PKM (0.57) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL1980863 0.86 ALDH1A1 (0.57) PKMMAPTALDH1A1HTTHCRTR1
SCHEMBL2000687 0.86 PKM (0.57) PKMMAPTALDH1A1HTTHCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240071588-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC (US) 2024-02-29 US disclosed
EP-3561077-B1 METHODS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER LAB (FR) 2022-12-21 EP disclosed
US-20200281501-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2020-09-10 US disclosed
US-10711314-B2 Methods for diagnosing IDH-mutant cell proliferation disorders AGIOS PHARMACEUTICALS, INC. (US) 2020-07-14 US disclosed
US-10610125-B2 Methods and compositions for cell-proliferation-related disorders AGIOS PHARMACEUTICALS, INC. (US) 2020-04-07 US disclosed
EP-3561077-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS Agios Pharmaceuticals, Inc. (US) 2019-10-30 EP disclosed
US-20190276894-A1 METHOD FOR TREATING CELL PROLIFERATION RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2019-09-12 US disclosed
EP-2406389-B1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS INC (US) 2019-05-08 EP disclosed
US-9982309-B2 Method for treating cell proliferation related disorders AGIOS PHARMACEUTICALS, INC. (US) 2018-05-29 US disclosed
US-20170325708-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2017-11-16 US disclosed
US-20130183281-A1 METHODS AND COMPOSITONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2013-07-18 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2013-02-07 US disclosed
EP-2509600-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION Agios Pharmaceuticals, Inc. (US) 2012-10-17 EP disclosed
US-20120121515-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS SERVIER PHARMACEUTICALS LLC 2012-05-17 US disclosed
WO-2011072174-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION AGIOS PHARMACEUTICALS, INC. (US) 2011-06-16 WO disclosed
WO-2011072174-A1 THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION AGIOS PHARMACEUTICALS, INC. (US) 2011-06-16 WO disclosed
WO-2011050210-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2011-04-28 WO disclosed
WO-2010105243-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS AGIOS PHARMACEUTICALS, INC. (US) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711314-B2 Methods for diagnosing IDH-mutant cell proliferation disorders MKI67, IDH1, IDH3A PKM 3304/4885MAPT 4240/4885ALDH1A1 489/4885
US-10610125-B2 Methods and compositions for cell-proliferation-related disorders MKI67, BRCA1, CLN6 PKM 4422/4885MAPT 4093/4885ALDH1A1 2917/4885
US-20170325708-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 PKM 4422/4885MAPT 4093/4885ALDH1A1 2917/4885
US-20120121515-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 PKM 4422/4885MAPT 4093/4885ALDH1A1 2917/4885
US-20240071588-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 PKM 4422/4885MAPT 4093/4885ALDH1A1 2917/4885
US-20130183281-A1 METHODS AND COMPOSITONS FOR CELL-PROLIFERATION-RELATED DISORDERS IDH2, IDH1, MKI67 PKM 2397/4885MAPT 2625/4885ALDH1A1 2900/4885
US-20130035329-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE MCL1, TP53, CD44 PKM 2448/4885MAPT 2835/4885ALDH1A1 2219/4885
US-20200281501-A1 METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS MKI67, BRCA1, CLN6 PKM 4422/4885MAPT 4093/4885ALDH1A1 2917/4885
US-20190276894-A1 METHOD FOR TREATING CELL PROLIFERATION RELATED DISORDERS IDH2, IDH1, IDH3A PKM 3067/4885MAPT 3070/4885ALDH1A1 1072/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.