Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837185 | 0.83 | MYC (0.42) | KMT2AHTR6MEN1KDM4EMYC | |
| SCHEMBL14837184 | 0.80 | LMNA (0.39) | KMT2APKMMEN1KDM4EHSD17B10 | |
| SCHEMBL14836947 | 0.78 | PARP1 (0.39) | KMT2AHTTSMN1; SMN2 | |
| SCHEMBL917709 | 0.74 | KDM4E (0.48) | KMT2AKDM4EHSD17B10ALDH1A1POLB | |
| SCHEMBL917909 | 0.74 | PARP1 (0.39) | HTR6HTT | |
| SCHEMBL918232 | 0.74 | PARP1 (0.35) | KMT2AMEN1HSD17B10ALDH1A1GAA | |
| SCHEMBL14837487 | 0.73 | ACHE (0.40) | KMT2AHTR6MEN1KDM4EALDH1A1 | |
| SCHEMBL14837347 | 0.72 | PARP1 (0.39) | KMT2AMEN1KDM4EALDH1A1POLB | |
| SCHEMBL917974 | 0.72 | CYP2A6 (0.39) | — | |
| SCHEMBL27796221 | 0.69 | PARP1 (0.32) | ALDH1A1HTTGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758864-B1 | Substituted tetrahydro-2H-isoquinolin-1-one derivatives, method for their preparation, and their use as medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2013-04-10 | — | — | EP | disclosed |