Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 5/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2513287 | 0.85 | ALDH1A1 (0.37) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2512774 | 0.85 | ALDH1A1 (0.37) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14837525 | 0.82 | GRM2 (0.41) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL473446 | 0.79 | RAB9A (0.55) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14837592 | 0.78 | ALDH1A1 (0.35) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5096582 | 0.74 | MAPT (0.41) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3824181 | 0.71 | MKNK1 (0.48) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5095741 | 0.67 | MAPK8 (0.39) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2903449 | 0.67 | KCNMA1 (0.45) | MAPTALDH1A1GAASMN1; SMN2TSHR | |
| SCHEMBL3821081 | 0.66 | ALDH1A1 (0.39) | LMNAMAPTALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576559-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2576559-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2576559-A1 | INHIBITORS OF JNK | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2011151357-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151357-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301170-A1 | Inhibitors of JNK | MAPK6, MAP3K6, MAPK1 | LMNA 1791/4885MAPT 1269/4885ALDH1A1 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.