Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.37 |
| ▸ | MAOB | P27338 | 9/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15671743 | 0.89 | MAOB (0.37) | MAOAMAOBPDE3BPDE3ATP53 | |
| SCHEMBL14816294 | 0.83 | TP53 (0.40) | MAOBPDE3BPDE3ATP53DRD2 | |
| SCHEMBL13111961 | 0.68 | MAOB (0.65) | MAOAMAOBPDE3BPDE3ADRD2 | |
| SCHEMBL14816097 | 0.67 | MAOB (0.42) | MAOAMAOBPDE3BPDE3ADRD2 | |
| SCHEMBL12359302 | 0.67 | MAOB (0.70) | MAOAMAOBPDE3BPDE3ADRD2 | |
| SCHEMBL31718445 | 0.63 | MAOB (0.67) | MAOAMAOBPDE3BPDE3ADRD2 | |
| SCHEMBL14800873 | 0.62 | POLB (0.48) | MAOAMAOBPDE3BPDE3ATP53 | |
| SCHEMBL31718471 | 0.62 | RAB9A (0.56) | MAOAMAOBMEN1CYP1A2KMT2A | |
| SCHEMBL6585538 | 0.62 | MAOB (0.68) | MAOAMAOBPDE3BPDE3ADRD2 | |
| SCHEMBL15854760 | 0.62 | DRD2 (0.52) | MAOBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760856-A1 | SELECTIVE NR2B ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049119-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |