Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710231 | 0.76 | MAPK1 (0.44) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL16815419 | 0.73 | GRM2 (0.37) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL24724928 | 0.72 | GRM2 (0.36) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL22303574 | 0.72 | CNR2 (0.41) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL23188013 | 0.72 | MAPT (0.40) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL12881335 | 0.71 | GRM2 (0.36) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL858824 | 0.70 | — | — | |
| SCHEMBL17844762 | 0.70 | — | — | |
| SCHEMBL24484496 | 0.69 | GRM2 (0.38) | GRM2POLBKMT2ANPBWR1MAPT | |
| SCHEMBL25447300 | 0.69 | CTSK (0.36) | GRM2POLBKMT2ANPBWR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013045461-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |