Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 8/20 | 0.48 |
| ▸ | GAA | P10253 | 8/20 | 0.48 |
| ▸ | SI | P14410 | 8/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874107 | 0.82 | RAB9A (0.53) | KDM4ERAB9ANPC1TNKSPARP1 | |
| SCHEMBL10285823 | 0.78 | MGAM (0.50) | MAPK8MAPK9MAPK10PARP1AURKA | |
| SCHEMBL13865841 | 0.78 | MGAM (0.52) | RAB9ANPC1MAPK8MAPK9MAPK10 | |
| SCHEMBL30615069 | 0.77 | MGAM (0.76) | KDM4ERAB9ANPC1TNKSPARP1 | |
| SCHEMBL5074029 | 0.77 | MGAM (0.76) | KDM4ERAB9ANPC1TNKSPARP1 | |
| SCHEMBL23886103 | 0.76 | GAA (0.64) | KDM4ERAB9ANPC1TNKSPARP1 | |
| SCHEMBL30019636 | 0.76 | GAA (0.64) | KDM4ERAB9ANPC1TNKSPARP1 | |
| SCHEMBL29101810 | 0.75 | RAB9A (0.64) | KDM4ERAB9ANPC1MAPK8MAPK9 | |
| SCHEMBL1901480 | 0.75 | RAB9A (1.00) | KDM4ERAB9ANPC1GAAALDH1A1 | |
| SCHEMBL29820118 | 0.75 | RAB9A (1.00) | KDM4ERAB9ANPC1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024257-A | Quinoxaline inhibitors of PI3K | GILEAD CALISTOGA LLC | 2014-09-03 | — | — | CN | disclosed |
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC | 2014-08-21 | — | — | US | disclosed |
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC | 2014-08-21 | — | — | US | disclosed |
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC | 2014-08-21 | — | — | US | disclosed |
| EP-2763994-A2 | NOVEL QUINOXALINE INHIBITORS OF PI3K | Gilead Calistoga LLC (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013052699-A2 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013052699-A2 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC (US) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | PIK3R5, PIK3CA, PIK3CD | KDM4E 2161/4885RAB9A 337/4885NPC1 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.