Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201033 | 0.90 | VEGFA (0.47) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL20137050 | 0.82 | VEGFA (0.54) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL23696886 | 0.79 | ALDH1A1 (0.51) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL30097974 | 0.79 | ALDH1A1 (0.51) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL20818719 | 0.78 | ALDH1A1 (0.58) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL30476377 | 0.78 | ALDH1A1 (0.58) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL23301626 | 0.78 | VEGFA (0.45) | ALDH1A1VEGFAEGLN1KDM4EPOLB | |
| SCHEMBL28456381 | 0.77 | VEGFA (0.47) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL30038645 | 0.77 | VEGFA (0.47) | MGLLALDH1A1VEGFAEGLN1KDM4E | |
| SCHEMBL20136985 | 0.77 | MGLL (0.62) | MGLLALDH1A1VEGFAEGLN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-B1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2013-04-10 | — | — | EP | disclosed |