Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28701016 | 0.90 | CHRM2 (0.50) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL23301148 | 0.83 | VEGFA (0.46) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL15192026 | 0.82 | CHRM2 (0.46) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL30576825 | 0.80 | CHRM2 (0.52) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL15264751 | 0.80 | VEGFA (0.45) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL15263897 | 0.79 | VEGFA (0.54) | VEGFAEGLN1MMP1MMP9MMP13 | |
| SCHEMBL3201033 | 0.79 | VEGFA (0.47) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL15265349 | 0.78 | ALDH1A1 (0.55) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL14847422 | 0.78 | MGLL (0.46) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL19992955 | 0.77 | MGLL (0.53) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051674-A1 | BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2022-09-07 | — | — | EP | disclosed |
| CN-114728936-A | Bifunctional compounds for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021083949-A1 | BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2021-05-06 | — | — | WO | disclosed |