Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000323 | 0.84 | RECQL (0.41) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL22623125 | 0.82 | RECQL (0.40) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL18314713 | 0.81 | PDE2A (0.33) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL15000243 | 0.79 | PDE10A (0.31) | PDE10A | |
| SCHEMBL14853184 | 0.78 | RECQL (0.37) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL15000234 | 0.77 | PDE2A (0.31) | PDE2ALMNASMN1; SMN2PDE10ATLR9 | |
| SCHEMBL12880861 | 0.74 | RECQL (0.46) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL14124200 | 0.74 | RECQL (0.46) | RECQLPOLBPDE2ALMNASMN1; SMN2 | |
| SCHEMBL10725037 | 0.74 | ALDH1A1 (0.37) | RECQLPOLBLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL26517813 | 0.72 | RECQL (0.41) | RECQLPOLBPDE2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107445-A1 | ENHANCEMENT OF THE EFFICACY OF SEROTONERGIC PSYCHEDELIC DRUGS IN THE TREATMENT OR PREVENTION OF CERTAIN NEUROPSYCHIATRIC DISORDERS THROUGH INHIBITION OF TYPE-9 PHOSPHODIESTERASES | FREEDOM BIOSCIENCES, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| US-11180494-B2 | Substituted amino acids as integrin inhibitors | PLIANT THERAPEUTICS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| EP-2982674-B1 | PYRIDINYLPYRAZOLOQUINOLINE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2017-10-25 | — | — | EP | disclosed |
| US-9550776-B2 | Pyridinylpyrazoloquinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-01-24 | — | — | US | disclosed |
| US-9550776-B2 | Pyridinylpyrazoloquinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-01-24 | — | — | US | disclosed |
| US-20160289225-A1 | PYRIDINYLPYRAZOLOQUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| EP-2982674-A1 | PYRIDINYLPYRAZOLOQUINOLINE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2016-02-10 | — | — | EP | disclosed |
| EP-2769980-B1 | PYRAZOLOQUINOLINE DERIVATIVE AS PDE9 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014163146-A1 | PYRIDINYLPYRAZOLOQUINOLINE COMPOUND | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2014-10-09 | — | — | WO | disclosed |
| EP-2769980-A1 | PYRAZOLOQUINOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2014-08-27 | — | — | EP | disclosed |
| US-20130296352-A1 | PYRAZOLOQUINOLINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-11-07 | — | — | US | disclosed |
| US-8563565-B2 | Pyrazoloquinoline derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-20130143907-A1 | PYRAZOLOQUINOLINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-06-06 | — | — | US | disclosed |
| WO-2013051639-A1 | PYRAZOLOQUINOLINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289225-A1 | PYRIDINYLPYRAZOLOQUINOLINE COMPOUNDS | REN, KCNQ2, KCNQ1 | RECQL 46/4885POLB 4017/4885PDE2A 106/4885 |
| US-20130143907-A1 | PYRAZOLOQUINOLINE DERIVATIVES | PDE2A, PDE3A, PDE3B | RECQL 240/4885POLB 3936/4885PDE2A 1/4885 |
| US-11180494-B2 | Substituted amino acids as integrin inhibitors | ITGB6, ITGA1, ITGB1 | RECQL 4829/4885POLB 4437/4885PDE2A 4637/4885 |
| US-20130296352-A1 | PYRAZOLOQUINOLINE DERIVATIVES | PDE2A, PDE3A, PDE3B | RECQL 240/4885POLB 3936/4885PDE2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.