Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Medronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 2/20 | 0.39 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | OTC | P00480 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medronic Acid SCHEMBL241941 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL12492957 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL19350137 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL78977 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL7743864 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2353950 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL9550946 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2823010 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1707898 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL3863755 | 0.97 | KDM4E (0.67) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135619-A | Scale inhibition base material and preparation method thereof, scale inhibition film, scale inhibition ball and scale inhibition sheet | 边文兵 | 2021-07-20 | — | — | CN | claimed |
| CN-103429528-B | The dirt prevented or reduce in Wet-process Phosphoric Acid Production | 塞特克技术公司 | 2016-08-10 | — | — | CN | claimed |
| US-8900539-B2 | Preventing or reducing scale in wet-process phosphoric acid production | CYTEC TECHNOLOGY CORP. (US) | 2014-12-02 | — | — | US | claimed |
| EP-2688837-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | Cytec Technology Corp. (US) | 2014-01-29 | — | — | EP | claimed |
| US-20120244058-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | CYTEC TECHNOLOGY CORP. (US) | 2012-09-27 | — | — | US | claimed |
| WO-2012128755-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | CYTEC TECHNOLOGY CORP. (US) | 2012-09-27 | — | — | WO | claimed |
| EP-2480496-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | Cytec Technology Corporation (US) | 2012-08-01 | — | — | EP | claimed |
| WO-2011038167-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | CYTEC TECHNOLOGY CORP. (US) | 2011-03-31 | — | — | WO | claimed |
| US-20110076219-A1 | PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION | CYTEC TECHNOLOGY CORP. (US) | 2011-03-31 | — | — | US | claimed |
| CN-1033143-C | Radiopharmaceutical formulations, their method of administration and process of preparation | DOW CHEMICAL CO (US) | 1996-10-30 | — | — | CN | claimed |
| CN-219839582-U | Scale inhibition filter core and water heater | 山东水创新材料有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-111484520-A | Ethylene diamine tetramethylene aluminum phosphonate flame retardant and preparation method and application thereof | 金发科技股份有限公司 | 2020-08-04 | — | — | CN | disclosed |
| CN-102712476-B | Preventing or reducing scale in wet-process phosphoric acid production | 塞特克技术公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-103429528-B | The dirt prevented or reduce in Wet-process Phosphoric Acid Production | 塞特克技术公司 | 2016-08-10 | — | — | CN | disclosed |
| US-9028787-B2 | Preventing or reducing scale in wet-process phosphoric acid production | CYTEC TECHNOLOGY CORP. (US) | 2015-05-12 | — | — | US | disclosed |
| US-5965505-A | TIME-RELEASE AGENTS COMPRISING AN ORGANIC PEROXYACID BLEACH COATED WITH AN ORGANIC BINDER AND INORGANIC SALT, E.G. SULFATES, SILICATES AND/OR CARBONATES; DISCOLORATION INHIBITION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| WO-1996001309-A1 | BLEACHING COMPOSITIONS | WARWICK INTERNATIONAL GROUP LIMITED (GB) | 1996-01-18 | — | — | WO | disclosed |
| EP-0603586-A1 | Photographic developing solution | ILFORD Limited (GB) | 1994-06-29 | — | — | EP | disclosed |
| US-4781984-A | Aromatic polyether resins having improved adhesion | THE DOW CHEMICAL COMPANY (US) | 1988-11-01 | — | — | US | disclosed |
| US-4777091-A | BETTER ADHESION OF POLYETHER COATINGS | THE DOW CHEMICAL COMPANY (US) | 1988-10-11 | — | — | US | disclosed |