Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Medronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 2/20 | 0.39 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | OTC | P00480 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medronic Acid SCHEMBL241941 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1485658 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL12492957 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL19350137 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL7743864 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2353950 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL9550946 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2823010 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1707898 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL3863755 | 0.97 | KDM4E (0.67) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5500 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098196-A1 | CHEMICAL-MECHANICAL POLISHING COMPOSITION FOR SILVER POLISHING | ENTEGRIS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-3613834-B1 | TREATMENT COMPOSITIONS COMPRISING LOW LEVELS OF AN OLIGOAMINE | PROCTER & GAMBLE (US) | 2026-04-01 | — | — | EP | claimed |
| US-20260078296-A1 | SUSTAINED-RELEASE SCALE INHIBITORS | Materials Engineering and Technical Support Services (US) | 2026-03-19 | — | — | US | claimed |
| US-12559704-B2 | Microelectronic device cleaning composition | ENTEGRIS, INC. (US) | 2026-02-24 | — | — | US | claimed |
| US-20260042976-A1 | COMPOSITIONS AND METHODS OF USE THEREOF | FUJIFILM ELECTRONIC MAT USA INC (US) | 2026-02-12 | — | — | US | claimed |
| US-20260031399-A1 | SECONDARY BATTERY AND PREPARATION METHOD THEREFOR, AND ELECTRIC DEVICE | CONTEMPORARY AMPEREX TECHNOLOGY CO., LIMITED (CN) | 2026-01-29 | — | — | US | claimed |
| WO-2025261904-A1 | PRESERVATIVE BLEND WITH INCREASED EFFICACY | ARCH UK BIOCIDES LIMITED (GB) | 2025-12-26 | — | — | WO | claimed |
| EP-4646235-A1 | ALPHA-EMITTING RADIONUCLIDES FOR USE IN THE TREATMENT OF PERITONEAL CANCER | Oncoinvent AS (NO) | 2025-11-12 | — | — | EP | claimed |
| EP-4643371-A1 | COMPOSITION FOR SELECTIVELY REMOVING OXIDE COMPOUNDS AND ETCHING RESIDUES OF ONE OR BOTH OF CO AND CU | BASF SE (DE) | 2025-11-05 | — | — | EP | claimed |
| EP-4632054-A1 | DETERGENT COMPOSITION | BELINKA PERKEMIJA kemicna industrija, d.o.o. (SI) | 2025-10-15 | — | — | EP | claimed |
| US-4401509-A | THIOSULFATE AND AN UNSATURATED ALCOHOL AS PEROXIDE STABILIZER | FMC CORPORATION (US) | 1983-08-30 | — | — | US | claimed |
| US-4362706-A | ORGANIC PHOSPHONIC ACID | FMC CORPORATION (US) | 1982-12-07 | — | — | US | claimed |
| US-4306991-A | STYRENESULFONIC ACID-MALEIC ACID COPOLYMER, ORGANIC PHOSPHONIC ACID COMPOUND | CHEMED CORPORATION (US) | 1981-12-22 | — | — | US | claimed |
| US-4283302-A | WASHING DETERGENTS | LEVER BROTHERS COMPANY (US) | 1981-08-11 | — | — | US | claimed |
| US-4255259-A | SULFONATED MALEIC ACID OR ANHYDRIDE-STYRENE COPOLYMER AND AN ORGANIC PHOSPHONIC ACID, BOILER WATER SYSTEMS | CHEMED CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
| US-4246030-A | AMINO ALKYLENE PHOSPHONIC ACID OR ITS DERIVATIVE | THE MOGUL CORPORATION (US) | 1981-01-20 | — | — | US | claimed |
| US-4143128-A | A POLYMETHYLENEDIAMINE TETRA(METHYLENE PHOSPHONIC ACID) | COLGATE PALMOLIVE COMPANY (US) | 1979-03-06 | — | — | US | claimed |
| US-4138353-A | ANTISCALING AGENTS | THE MOGUL CORPORATION (US) | 1979-02-06 | — | — | US | claimed |
| US-4032379-A | FILMING AGENTS | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1977-06-28 | — | — | US | claimed |
| US-4013586-A | Vanadium catalysts prepared with phosphonates | MONSANTO COMPANY (US) | 1977-03-22 | — | — | US | claimed |