Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Medronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 2/20 | 0.39 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | OTC | P00480 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medronic Acid SCHEMBL241941 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1485658 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL12492957 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL19350137 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL78977 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL7743864 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL2353950 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL9550946 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL1707898 | 1.00 | KDM4E (0.71) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Medronic Acid SCHEMBL3863755 | 0.97 | KDM4E (0.67) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11628127-B2 | Composition for lightening or dyeing keratin fibers with a low amount of oxidizing agent | WELLA OPERATIONS US, LLC (US) | 2023-04-18 | — | — | US | claimed |
| WO-2012154498-A2 | REMOVAL OF METAL IMPURITIES FROM SILICON SURFACES FOR SOLAR CELL AND SEMICONDUCTOR APPLICATIONS | ADVANCED TECHNOLOGY MATERIALS, INC. (US) | 2012-11-15 | — | — | WO | claimed |
| EP-0819164-B1 | DETERGENT COMPOSITION COMPRISING SOURCE OF HYDROGEN PEROXIDE AND PROTEASE ENZYME | PROCTER & GAMBLE (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2024126047-A1 | BLEACH POWDER AND METHOD FOR BLEACHING HAIR | WELLA GERMANY GMBH (DE) | 2024-06-20 | — | — | WO | disclosed |
| EP-4385485-A1 | BLEACH POWDER AND METHOD FOR BLEACHING HAIR | Wella Germany GmbH (DE) | 2024-06-19 | — | — | EP | disclosed |
| US-20230398042-A1 | COSMETIC COMPOSITIONS AND USES THEREOF | JPMORGAN CHASE BANK, N.A. | 2023-12-14 | — | — | US | disclosed |
| US-20230381070-A1 | COSMETIC COMPOSITIONS AND USES THEREOF | COTY INC. | 2023-11-30 | — | — | US | disclosed |
| EP-3773923-B1 | HAIR TREATMENT COMPOSITIONS, SYSTEMS, DEVICES AND METHODS | WELLA INT OPERATIONS SWITZERLAND SARL (CH) | 2023-10-04 | — | — | EP | disclosed |
| WO-2023152322-A1 | HAIR COLORING USING OXIDATIVE DYE PRECURSORS COMPRISING PYRAZOLE PRIMARIES AND COUPLERS, IN COMBINATION WITH SOLUBILIZED VAT DYES, FOR IMPROVING COLOR WASH FASTNESS | WELLA GERMANY GMBH (DE) | 2023-08-17 | — | — | WO | disclosed |
| EP-4225256-A1 | COSMETIC COMPOSITIONS AND USES THEREOF | Coty Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-4225264-A1 | COSMETIC COMPOSITIONS AND USES THEREOF | Coty Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-1847249-A1 | HAIRDYE COMPOSITION | Kao Corporation (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-7083655-B2 | Hair dye composition | KAO CORPORATION (JP) | 2006-08-01 | — | — | US | disclosed |
| US-7056355-B2 | Hair dye composition and dyeing method | KAO CORPORATION (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20050015896-A1 | Hair dye composition and dyeing method | KAO CORPORATION (JP) | 2005-01-27 | — | — | US | disclosed |
| US-20050003988-A1 | Enzyme bleach lipophilic fluid cleaning compositions | THE PROCTER & GAMBLE COMPANY | 2005-01-06 | — | — | US | disclosed |
| EP-1398022-A1 | Hair dye composition comprising an azo dye containing a dissociative proton, method and use | Kao Corporation (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-20040019982-A1 | Hair dye composition | KAO CORPORATION (JP) | 2004-02-05 | — | — | US | disclosed |
| EP-1369105-A1 | Hair dye composition | Kao Corporation (JP) | 2003-12-10 | — | — | EP | disclosed |
| US-3959361-A | Process of producing amino methylene phosphonic acids | JOH. A. BENCKISER GMBH (DT) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019982-A1 | Hair dye composition | CYBA, SDHB, S100B | PDE3A 3500/4885PDE4D 4161/4885KDM4E 760/4885 |
| US-20050015896-A1 | Hair dye composition and dyeing method | SULT1A1, CYP21A2, SULT2A1 | PDE3A 2493/4885PDE4D 2507/4885KDM4E 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.