Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045900 | 0.94 | HRH3 (0.66) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL1143656 | 0.89 | NPC1 (0.85) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2232053 | 0.88 | HRH3 (0.63) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2231843 | 0.87 | HRH3 (0.64) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2236278 | 0.87 | HRH3 (0.60) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2233922 | 0.87 | HRH3 (0.64) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL31484892 | 0.86 | HRH3 (0.78) | NPC1RAB9ATP53SMN1; SMN2KDM4E | |
| SCHEMBL2363227 | 0.85 | HRH3 (0.55) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL7811609 | 0.84 | NPC1 (0.78) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2195635 | 0.84 | KDM4E (0.60) | SIGMAR1NPC1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-12-20 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-20150231132-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2015-08-20 | — | — | US | disclosed |
| US-8916705-B2 | Procaspase-activating compounds and compositions | The Board of Trustees of The University of Illilnois (US) | 2014-12-23 | — | — | US | disclosed |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | The Board of Trustees of the University lllinois (US) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150231132-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | CASP3, CASP5, CASP6 | SIGMAR1 4613/4885NPC1 2255/4885RAB9A 3591/4885 |
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | CASP3, CASP5, CASP6 | SIGMAR1 4613/4885NPC1 2255/4885RAB9A 3591/4885 |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | CASP3, CASP5, CASP6 | SIGMAR1 4673/4885NPC1 2639/4885RAB9A 3508/4885 |
| US-10022371-B2 | Procaspase-activating compounds and methods | CASP3, CASP5, CASP6 | SIGMAR1 4613/4885NPC1 2255/4885RAB9A 3591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.