Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.72 |
| ▸ | PKM | P14618 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 10/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | CASP7 | P55210 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248226 | 0.85 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL20250909 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL14865018 | 0.80 | KDM4E (0.85) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL19275255 | 0.80 | ALDH1A1 (0.77) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL14865002 | 0.76 | KDM4E (0.86) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL20248183 | 0.75 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL242401 | 0.74 | PTGS1 (0.62) | KDM4EALDH1A1HSD17B10POLBPKM | |
| SCHEMBL243617 | 0.74 | MAPT (0.74) | KDM4EALDH1A1HSD17B10POLBMEN1 | |
| SCHEMBL14865007 | 0.73 | MAPT (1.00) | KDM4EALDH1A1HSD17B10POLBMEN1 | |
| SCHEMBL15862515 | 0.73 | MAPT (0.72) | KDM4EALDH1A1HSD17B10POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581451-A1 | Compounds for inhibiting mammalian s-nitrosoglutathione reductase | Indiana University Research and Technology Corporation (US) | 2013-04-17 | — | — | EP | disclosed |