Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.86 |
| ▸ | MAPT | P10636 | 8/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.86 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.86 |
| ▸ | GAA | P10253 | 5/20 | 0.86 |
| ▸ | HPGD | P15428 | 5/20 | 0.86 |
| ▸ | POLB | P06746 | 4/20 | 0.86 |
| ▸ | MEN1 | O00255 | 3/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.86 |
| ▸ | CASP1 | P29466 | 3/20 | 0.86 |
| ▸ | USP2 | O75604 | 2/20 | 0.86 |
| ▸ | CASP7 | P55210 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
| ▸ | GLA | P06280 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865018 | 0.90 | KDM4E (0.85) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL20248187 | 0.85 | ALDH1A1 (0.85) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL19275255 | 0.85 | ALDH1A1 (0.77) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL9763051 | 0.76 | ALDH1A1 (0.76) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL14865000 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL20248152 | 0.75 | ALDH1A1 (0.69) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL19270610 | 0.75 | ALDH1A1 (0.79) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL14865007 | 0.73 | MAPT (1.00) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL7226330 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL14865047 | 0.72 | MAPT (1.00) | KDM4EALDH1A1MAPTHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581451-A1 | Compounds for inhibiting mammalian s-nitrosoglutathione reductase | Indiana University Research and Technology Corporation (US) | 2013-04-17 | — | — | EP | disclosed |