Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.85 |
| ▸ | MAPT | P10636 | 7/20 | 0.85 |
| ▸ | HPGD | P15428 | 6/20 | 0.85 |
| ▸ | GAA | P10253 | 6/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.85 |
| ▸ | MEN1 | O00255 | 5/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.85 |
| ▸ | POLB | P06746 | 4/20 | 0.85 |
| ▸ | CASP1 | P29466 | 2/20 | 0.85 |
| ▸ | USP2 | O75604 | 2/20 | 0.85 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | CASP7 | P55210 | 1/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.85 |
| ▸ | GLA | P06280 | 3/20 | 0.75 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865002 | 0.90 | KDM4E (0.86) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL19275255 | 0.89 | ALDH1A1 (0.77) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL19270610 | 0.85 | ALDH1A1 (0.79) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL17211755 | 0.82 | CNKSR1 (1.00) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL14285635 | 0.82 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL14865000 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL17211683 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL17213444 | 0.78 | MAPT (0.55) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL17211702 | 0.77 | ALDH1A1 (0.85) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL17211717 | 0.77 | CNKSR1 (0.85) | KDM4EALDH1A1HSD17B10MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160108031-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITAT DUSSELDORF (DE) | 2016-04-21 | — | — | US | claimed |
| EP-2991963-A2 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | Heinrich-Heine-Universität Düsseldorf (DE) | 2016-03-09 | — | — | EP | claimed |
| WO-2014177464-A2 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2014-11-06 | — | — | WO | claimed |
| EP-2991963-B1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2021-07-07 | — | — | EP | disclosed |
| EP-2991963-B1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2021-07-07 | — | — | EP | disclosed |
| US-20210147415-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2021-05-20 | — | — | US | disclosed |
| US-20210147415-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2021-05-20 | — | — | US | disclosed |
| US-20170241981-A1 | PLASMA MEMBRANE CITRATE TRANSPORTER FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2017-08-24 | — | — | US | disclosed |
| US-20160108031-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITAT DUSSELDORF (DE) | 2016-04-21 | — | — | US | disclosed |
| US-20160108031-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITAT DUSSELDORF (DE) | 2016-04-21 | — | — | US | disclosed |
| EP-2991963-A2 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | Heinrich-Heine-Universität Düsseldorf (DE) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014177464-A2 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014177464-A2 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2014-11-06 | — | — | WO | disclosed |
| EP-2581451-A1 | Compounds for inhibiting mammalian s-nitrosoglutathione reductase | Indiana University Research and Technology Corporation (US) | 2013-04-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108031-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | RUNX1, ETV6, NPM1 | KDM4E 2323/4885ALDH1A1 4852/4885HSD17B10 2447/4885 |
| US-20170241981-A1 | PLASMA MEMBRANE CITRATE TRANSPORTER FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER | SLC16A1, SLC16A7, SLC16A3 | KDM4E 3129/4885ALDH1A1 1648/4885HSD17B10 846/4885 |
| US-20210147415-A1 | INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION | RUNX1, ETV6, NPM1 | KDM4E 2323/4885ALDH1A1 4852/4885HSD17B10 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.