Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893300 | 0.82 | TSHR (0.37) | TSHRCYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL28095673 | 0.78 | ALOX5 (0.40) | TSHRCYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL12310754 | 0.74 | ALOX5 (0.41) | TSHRCYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL23516198 | 0.73 | SLC7A5 (0.36) | TSHRCYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL13966060 | 0.73 | LTA4H (0.45) | KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2880798 | 0.73 | ALOX5 (0.39) | TSHRCYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL12311962 | 0.71 | — | — | |
| SCHEMBL94688 | 0.71 | — | — | |
| SCHEMBL827372 | 0.71 | ALOX5 (0.35) | CYP2D6KMT2ALMNAALOX5CES2 | |
| SCHEMBL12260273 | 0.71 | ALOX5 (0.39) | TSHRCYP2D6CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485089-B1 | COMBINATION TREATMENTS FOR CHEMOKINE-MEDIATED DISEASES | MERCK SHARP & DOHME (US) | 2013-04-17 | — | — | EP | disclosed |