Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077090 | 0.87 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2ALOX5 | |
| SCHEMBL12767085 | 0.86 | SLC6A2 (0.40) | KMT2ASLC6A4SLC6A3SLC6A2AGTR2 | |
| SCHEMBL12767088 | 0.84 | ALOX5 (0.40) | SLC6A4SLC6A3SLC6A2ALOX5AGTR2 | |
| SCHEMBL3637292 | 0.83 | NPC1 (0.47) | MEN1KMT2ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3408775 | 0.82 | ALOX5 (0.41) | MEN1KMT2AALOX5TRPM8TDP1 | |
| SCHEMBL3408769 | 0.82 | ALOX5 (0.41) | MEN1KMT2AALOX5TRPM8TDP1 | |
| SCHEMBL3408772 | 0.82 | ALOX5 (0.41) | MEN1KMT2AALOX5TRPM8TDP1 | |
| SCHEMBL18380905 | 0.81 | ALDH1A1 (0.39) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL13953697 | 0.80 | ALOX5 (0.37) | ALOX5TRPM8 | |
| SCHEMBL16791621 | 0.79 | ALOX5 (0.39) | ALOX5TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300461-B1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |