Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19574651 | 0.85 | NPC1 (0.49) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL19574255 | 0.85 | POLB (0.43) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18928821 | 0.84 | AIMP2 (0.38) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9539850 | 0.82 | MEN1 (0.44) | P2RX7MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9926464 | 0.82 | P2RX7 (0.51) | P2RX7POLBKDM4EHDAC3HDAC1 | |
| SCHEMBL17790718 | 0.82 | P2RX7 (0.51) | P2RX7MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14729157 | 0.80 | NPC1 (0.46) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22904559 | 0.80 | SRC (0.69) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8569927 | 0.80 | MEN1 (0.49) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL1257786 | 0.79 | NPSR1 (0.45) | P2RX7NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016950-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |