Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805217 | 0.89 | P2RX7 (0.36) | BDKRB1P2RX7CTDSP1CNR2HTT | |
| SCHEMBL197308 | 0.87 | BDKRB1 (0.36) | BDKRB1P2RX7CTDSP1CNR2HTT | |
| SCHEMBL2808176 | 0.87 | BDKRB1 (0.36) | BDKRB1P2RX7CTDSP1CNR2HTT | |
| SCHEMBL10066086 | 0.83 | CNR2 (0.36) | P2RX7CNR1CNR2KDM4E | |
| SCHEMBL15460097 | 0.83 | ALOX15 (0.36) | P2RX7CNR1MAPK1CNR2 | |
| SCHEMBL186187 | 0.83 | TRPV1 (0.36) | P2RX7CTDSP1HTT | |
| SCHEMBL2805848 | 0.82 | BDKRB1 (0.39) | BDKRB1CNR2 | |
| SCHEMBL10071820 | 0.82 | EPHX2 (0.33) | ROCK2ROCK1BDKRB1P2RX7CNR2 | |
| SCHEMBL2805120 | 0.82 | CNR2 (0.38) | BDKRB1P2RX7CNR1CNR2KDM4E | |
| SCHEMBL2809983 | 0.82 | OPRL1 (0.36) | BDKRB1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |