Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 8/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2811762 | 0.95 | BDKRB1 (0.35) | BDKRB1CNR1EPHX2PDE2ANTRK1 | |
| SCHEMBL2806388 | 0.88 | HDAC3 (0.38) | BDKRB1EPHX2NTRK1HDAC6P2RX7 | |
| SCHEMBL2811531 | 0.88 | BDKRB1 (0.37) | BDKRB1CNR1NTRK1P2RX7RAF1 | |
| SCHEMBL2805174 | 0.87 | BDKRB1 (0.41) | BDKRB1CNR1NTRK1HDAC6MAPK9 | |
| SCHEMBL10070758 | 0.86 | EPHX2 (0.40) | BDKRB1EPHX2P2RX7 | |
| SCHEMBL185850 | 0.84 | FAAH (0.38) | BDKRB1CNR1EPHX2NTRK1MAPK9 | |
| SCHEMBL2809623 | 0.84 | BDKRB1 (0.39) | BDKRB1HDAC6MAPK9MAPK10 | |
| SCHEMBL185861 | 0.82 | BDKRB1 (0.37) | BDKRB1CNR1EPHX2 | |
| SCHEMBL16404411 | 0.81 | ROCK2 (0.34) | BDKRB1CXCR2 | |
| SCHEMBL9892777 | 0.81 | PTGES (0.34) | BDKRB1CNR1EPHX2MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |