SCHEMBL14865879

SCHEMBL14865879

CCCC1CCCCNC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
HRH3 Q9Y5N1 3/20 0.40
HRH4 Q9H3N8 2/20 0.40
KMT2A Q03164 1/20 0.39
CPN1 P15169 1/20 0.35
CPB2 Q96IY4 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
EED O75530 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
BACE1 P56817 2/20 0.33
KCNH2 Q12809 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
NAAA Q02083 1/20 0.33
CHRNA7 P36544 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21140619 0.98 CYP1A2 (0.45) CYP1A2HRH3HRH4KMT2ACPN1
SCHEMBL10346166 0.98 CYP1A2 (0.45) CYP1A2HRH3HRH4KMT2ACPN1
SCHEMBL17690276 0.93
SCHEMBL893581 0.93
Ammonia Solution, Strong SCHEMBL27321717 0.91 HRH3 (0.44) CYP1A2HRH3HRH4KMT2ACPN1
Hydrochloric Acid SCHEMBL31482227 0.91 HRH3 (0.44) CYP1A2HRH3HRH4KMT2ACPN1
Hydrochloric Acid SCHEMBL4428244 0.91 HRH3 (0.44) CYP1A2HRH3HRH4KMT2ACPN1
SCHEMBL16925545 0.86 CYP1A2 (0.63) CYP1A2HRH3HRH4KMT2ABACE1
Piperidine SCHEMBL28557465 0.84 CYP1A2 (0.54) CYP1A2CA1CA2CA4CHRNA7
SCHEMBL11633874 0.84 CYP1A2 (0.50) CYP1A2HRH3HRH4KMT2ANAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10227314-B2 Cystathionine-gamma-lyase (CSE) inhibitors SOVA PHARMACEUTICALS, INC. (US) 2019-03-12 US disclosed
US-20170334866-A1 CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS SOVA PHARMACEUTICALS, INC. 2017-11-23 US disclosed
US-20170327478-A1 CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS SOVA PHARMACEUTICALS, INC. 2017-11-16 US disclosed
WO-2017174621-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-12 WO disclosed
EP-3153023-A1 BENZOXAZOLE KINASE INHIBITORS AND METHODS OF USE Intellikine, LLC (US) 2017-04-12 EP disclosed
US-20130252967-A1 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS AFRAXIS, INC. (US) 2013-09-26 US disclosed
US-20130231348-A1 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS AFRAXIS, INC. (US) 2013-09-05 US disclosed
US-20130158043-A1 PAK INHIBITORS FOR THE TREATMENT OF CANCER AFRAXIS, INC. (US) 2013-06-20 US disclosed
US-20130158043-A1 PAK INHIBITORS FOR THE TREATMENT OF CANCER AFRAXIS, INC. (US) 2013-06-20 US disclosed
US-20130096115-A1 METHODS FOR TREATING AUTISM AFRAXIS, INC. (US) 2013-04-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170334866-A1 CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS CBS, CTH, BHMT CYP1A2 3163/4885HRH3 3120/4885HRH4 3592/4885
US-20170327478-A1 CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS CBS, CTH, BHMT CYP1A2 3163/4885HRH3 3120/4885HRH4 3592/4885
US-20130252967-A1 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS PAK2, PAK3, PAK6 CYP1A2 4177/4885HRH3 1785/4885HRH4 2231/4885
US-20130231348-A1 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS PAK2, PAK3, PAK5 CYP1A2 3303/4885HRH3 1290/4885HRH4 2122/4885
US-10227314-B2 Cystathionine-gamma-lyase (CSE) inhibitors CBS, CTH, BHMT CYP1A2 3163/4885HRH3 3120/4885HRH4 3592/4885
US-20130158043-A1 PAK INHIBITORS FOR THE TREATMENT OF CANCER PAK5, PAK2, PAK6 CYP1A2 4815/4885HRH3 4198/4885HRH4 4698/4885
US-20130096115-A1 METHODS FOR TREATING AUTISM PAK2, PAK3, PAK4 CYP1A2 4769/4885HRH3 3614/4885HRH4 4333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.