Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.40 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428650 | 0.95 | CASR (0.42) | CASRMAOBMAOAMAPTKDM4E | |
| SCHEMBL14867280 | 0.91 | CASR (0.37) | CASRMAOBMAOAMAPTKDM4E | |
| SCHEMBL14867341 | 0.90 | LMNA (0.41) | MAOBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL2427232 | 0.84 | LMNA (0.46) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14867288 | 0.82 | MAOB (0.41) | CASRMAOBMAOAMAPTTP53 | |
| SCHEMBL12324331 | 0.81 | MAPT (0.44) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14867304 | 0.80 | S1PR4 (0.35) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14867285 | 0.79 | MAPT (0.46) | MAOBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL14867274 | 0.79 | HPRT1 (0.39) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14871602 | 0.77 | MAPT (0.44) | MAPTKDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | GNAQ, HCCS, SDHA | CASR 4854/4885MAOB 1940/4885MAOA 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.