Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875390 | 0.85 | ALDH1A1 (0.39) | ALDH1A1LMNAMEN1GAAKMT2A | |
| SCHEMBL27154594 | 0.83 | NPSR1 (0.50) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL14875550 | 0.79 | ALDH1A1 (0.46) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL27308580 | 0.78 | ADORA1 (0.53) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL27153493 | 0.75 | ALDH1A1 (0.49) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL17109829 | 0.74 | KDM4E (0.49) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL17109828 | 0.74 | KDM4E (0.49) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL3718737 | 0.73 | ALDH1A1 (0.52) | NPSR1ALDH1A1LMNAMEN1GAA | |
| SCHEMBL6212815 | 0.73 | HTR1D (0.62) | NPSR1ALDH1A1MAPTKDM4ETHRB | |
| SCHEMBL8040438 | 0.73 | NAMPT (0.54) | NPSR1ALDH1A1LMNAMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765771-B2 | Condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same | KOWA CO., LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20130102621-A1 | NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME | KOWA CO., LTD. (JP) | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102621-A1 | NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME | IAPP, GPR119, RNASE1 | NPSR1 1639/4885ALDH1A1 3659/4885LMNA 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.