Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617437 | 0.81 | TLR4 (0.49) | GAAALDH1A1TLR4SMN1; SMN2NPSR1 | |
| SCHEMBL8020503 | 0.81 | TSHR (0.35) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL2721962 | 0.78 | TSHR (0.36) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL22468826 | 0.78 | TSHR (0.36) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL29529763 | 0.78 | TSHR (0.36) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL6475425 | 0.76 | MCL1 (0.41) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL8744677 | 0.75 | CA1 (0.35) | GAAALDH1A1CYP3A4TSHRTP53 | |
| SCHEMBL10588700 | 0.75 | GAA (0.34) | GAAALDH1A1CYP3A4TLR4TSHR | |
| SCHEMBL11782843 | 0.75 | CYP1A2 (0.38) | ALDH1A1TLR4MAPK1SMN1; SMN2KDM4E | |
| SCHEMBL10231781 | 0.74 | ALDH1A1 (0.35) | GAAALDH1A1CYP3A4TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329254-B2 | Process for the preparation of 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide and intermediates thereof | AOP ORPHAN PHARMACEUTICALS AG (AT) | 2019-06-25 | — | — | US | disclosed |
| US-20160304455-A1 | PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES THEREOF | AOP ORPHAN IP AG (LI) | 2016-10-20 | — | — | US | disclosed |
| US-20140303382-A1 | PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2014-10-09 | — | — | US | disclosed |
| EP-2768807-A1 | PROCESSES FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND OF ITS PRECURSORS | Siena Biotech S.p.A. (IT) | 2014-08-27 | — | — | EP | disclosed |
| CN-103958467-A | Process for preparing 6-chloro-2, 3,4, 9-tetrahydro-1H-carbazole-1-carboxamide and precursors thereof | SIENA BIOTECH SPA | 2014-07-30 | — | — | CN | disclosed |
| WO-2013057258-A1 | PROCESSES FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND OF ITS PRECURSORS | SIENA BIOTECH S.P.A. (IT) | 2013-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303382-A1 | PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES THEREOF | CYP2B6, CYP2D6, CYP2C9 | GAA 2173/4885ALDH1A1 276/4885CYP3A4 5/4885 |
| US-10329254-B2 | Process for the preparation of 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide and intermediates thereof | CYP2B6, CYP2D6, CYP2C9 | GAA 2173/4885ALDH1A1 276/4885CYP3A4 5/4885 |
| US-20160304455-A1 | PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES THEREOF | CYP2B6, CYP2D6, CYP2C9 | GAA 2173/4885ALDH1A1 276/4885CYP3A4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.