Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121604 | 0.83 | L3MBTL3 (0.34) | HRH3KCNH2 | |
| SCHEMBL602034 | 0.81 | HSD11B1 (0.35) | KMT2ATACR1MAPK1 | |
| SCHEMBL602035 | 0.81 | HSD11B1 (0.35) | KMT2ATACR1MAPK1 | |
| Hydrochloric Acid SCHEMBL3665053 | 0.81 | L3MBTL3 (0.33) | KMT2AHRH3KCNH2MAPK1 | |
| SCHEMBL4788247 | 0.80 | CHRM2 (0.34) | KMT2APIK3CAHRH3 | |
| SCHEMBL4788242 | 0.80 | CHRM2 (0.34) | KMT2APIK3CAHRH3 | |
| SCHEMBL10203554 | 0.79 | HRH3 (0.33) | HRH3CYP2D6KCNH2MAPK1 | |
| SCHEMBL606461 | 0.79 | HRH3 (0.33) | HRH3CYP2D6KCNH2MAPK1 | |
| SCHEMBL14042280 | 0.79 | DPP4 (0.36) | NPC1RAB9AKMT2AHRH3CYP2D6 | |
| SCHEMBL4748656 | 0.79 | DPP4 (0.36) | NPC1RAB9AKMT2AHRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426443-B2 | Compounds which have activity at M1 receptor and their uses in medicine | GLAXO GROUP LIMITED (GB) | 2013-04-23 | — | — | US | disclosed |