Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878519 | 0.84 | SYK (0.42) | ATMCTSKCTSLCTSSSYK | |
| SCHEMBL13032794 | 0.78 | HDAC6 (0.47) | ATMSYKHDAC8 | |
| SCHEMBL14370507 | 0.77 | ATM (0.62) | ATMCTSKCTSLCTSSSYK | |
| SCHEMBL7616339 | 0.77 | MEN1 (0.44) | ATMCTSKCTSLCTSSALDH1A1 | |
| SCHEMBL14878522 | 0.77 | SYK (0.55) | ATMCTSKCTSLCTSSSYK | |
| SCHEMBL3700787 | 0.77 | L3MBTL1 (0.47) | ATMCTSKCTSLCTSSALDH1A1 | |
| SCHEMBL6419856 | 0.76 | MEN1 (0.44) | ATMCTSKCTSLCTSSITGB3 | |
| SCHEMBL6856061 | 0.74 | MDM2 (0.46) | KMT2A | |
| SCHEMBL8717149 | 0.73 | CA1 (0.53) | ALDH1A1CA1CA2MEN1KMT2A | |
| SCHEMBL6419860 | 0.72 | ATM (0.47) | ATMCTSKCTSLCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9476045-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20150073133-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2015-03-12 | — | — | US | disclosed |
| US-8865677-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130281685-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2013-10-24 | — | — | US | disclosed |
| US-8426377-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2013-04-23 | — | — | US | disclosed |