Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878516 | 0.84 | ATM (0.50) | SYKATMCTSKCTSLCTSS | |
| SCHEMBL13032794 | 0.72 | HDAC6 (0.47) | SYKATMHDAC8 | |
| SCHEMBL11886701 | 0.72 | SYK (0.54) | SYKATMCTSKCTSLCTSS | |
| SCHEMBL27081257 | 0.72 | KIF11 (0.41) | — | |
| SCHEMBL27081261 | 0.72 | KIF11 (0.41) | — | |
| SCHEMBL27081269 | 0.72 | MEN1 (0.38) | — | |
| SCHEMBL27081272 | 0.72 | MEN1 (0.38) | — | |
| SCHEMBL7616339 | 0.71 | MEN1 (0.44) | ATMCTSKCTSLCTSSCA1 | |
| SCHEMBL14370507 | 0.69 | ATM (0.62) | SYKATMCTSKCTSLCTSS | |
| SCHEMBL6856061 | 0.69 | MDM2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426377-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2013-04-23 | — | — | US | disclosed |