Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.48 |
| ▸ | PPM1D | O15297 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | GNA15 | P30679 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005946 | 0.88 | HIF1A (0.53) | HIF1AHDAC8SENP1FFAR1CETP | |
| SCHEMBL5179550 | 0.83 | HIF1A (0.68) | HIF1AHDAC8SENP1FFAR1HDAC6 | |
| SCHEMBL15761746 | 0.83 | HIF1A (0.60) | HIF1AHDAC8SENP1HDAC1HDAC6 | |
| SCHEMBL14878570 | 0.81 | HDAC8 (0.53) | HDAC8FFAR1HDAC1HDAC6TDP1 | |
| SCHEMBL25805521 | 0.78 | DDR2 (0.58) | HIF1AHDAC8HDAC1HDAC6PPM1D | |
| SCHEMBL521860 | 0.77 | AKR1C3 (0.68) | HDAC8ALDH1A1SMN1; SMN2 | |
| SCHEMBL15761753 | 0.76 | HIF1A (0.85) | HIF1AHDAC8SENP1HDAC6LOXL2 | |
| SCHEMBL14420824 | 0.74 | LOXL2 (0.58) | HIF1ASENP1HDAC1PPM1DLOXL2 | |
| SCHEMBL15761754 | 0.74 | HIF1A (0.58) | HIF1AHDAC8SENP1HDAC1HDAC6 | |
| SCHEMBL15755934 | 0.74 | HIF1A (0.58) | HIF1AHDAC8SENP1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426607-B2 | Substituted amino-benzimidazoles, medicaments comprimising said compound, their use and their method of manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-04-23 | — | — | US | disclosed |