SCHEMBL521860

SCHEMBL521860

COC(=O)c1cccc(Oc2ccccc2)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.68
HDAC8 Q9BY41 1/20 0.65
TSHR P16473 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.60
ERCC5 P28715 1/20 0.59
FEN1 P39748 1/20 0.59
RAB9A P51151 2/20 0.57
NPC1 O15118 2/20 0.56
PGR P06401 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.55
TP53 P04637 1/20 0.55
PKM P14618 1/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
MEN1 O00255 1/20 0.53
MAPT P10636 1/20 0.53
KMT2A Q03164 1/20 0.53
TNKS O95271 1/20 0.53
PARP15 Q460N3 1/20 0.53
PARP14 Q460N5 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2436534 0.94 L3MBTL1 (0.65) AKR1C3HDAC8TSHRL3MBTL1ERCC5
SCHEMBL883130 0.91 TNKS (0.60) AKR1C3HDAC8TSHRL3MBTL1RAB9A
SCHEMBL13087758 0.90 AKR1C3 (0.65) AKR1C3HDAC8TSHRL3MBTL1RAB9A
Diphenylether SCHEMBL10690245 0.89 TSHR (0.79) AKR1C3HDAC8TSHRL3MBTL1RAB9A
SCHEMBL14217726 0.88 L3MBTL1 (0.56) AKR1C3HDAC8TSHRL3MBTL1RAB9A
SCHEMBL5558318 0.88 SMN1; SMN2 (0.66) TSHRL3MBTL1RAB9ANPC1PGR
SCHEMBL25620305 0.88 MEN1 (0.59) AKR1C3HDAC8TSHRL3MBTL1RAB9A
SCHEMBL22210569 0.87 TSHR (0.59) AKR1C3HDAC8TSHRL3MBTL1ERCC5
SCHEMBL16247158 0.87 TSHR (0.59) AKR1C3HDAC8TSHRL3MBTL1ERCC5
SCHEMBL12260934 0.87 L3MBTL1 (0.55) AKR1C3HDAC8TSHRL3MBTL1ERCC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023212597-A1 CARBON DIOXIDE CAPTURE AND UTILIZATION AS A CLEAN FEEDSTOCK MICHIGAN TECHNOLOGICAL UNIVERSITY (US) 2023-11-02 WO claimed
CN-109096420-B Catalyst for olefin polymerization and olefin polymerization method 中国石油化工股份有限公司 2021-05-11 CN claimed
CN-109096419-A A kind of catalyst and olefine polymerizing process for olefinic polymerization 中国石油化工股份有限公司 2018-12-28 CN claimed
CN-109096425-A A kind of catalyst and olefine polymerizing process for olefinic polymerization 中国石油化工股份有限公司 2018-12-28 CN claimed
CN-107626316-A A kind of m-phenoxybenzoic acid methyl ester hydrogenation catalyst and preparation method thereof 南京大学扬州化学化工研究院 2018-01-26 CN claimed
CN-102675067-B A kind of method for catalyzing and synthesizing 3-phenoxy-benzaldehyde 南京大学扬州化学化工研究院 2017-12-22 CN claimed
CN-105272834-A Method for preparing m-phenoxy benzaldehyde YANGZHOU INST OF CHEMISTRY AND CHEMICAL ENGINEERING NANJING UNIVERSITY 2016-01-27 CN claimed
CN-105218337-A A kind of shortening prepares 3-phenoxy-benzaldehyde product separation method YANGZHOU INST OF CHEMISTRY AND CHEMICAL ENGINEERING NANJING UNIVERSITY 2016-01-06 CN claimed
CN-104230688-A Catalyzed synthesis method for m-phenoxy benzaldehyde ZIBO VOCATIONAL INST 2014-12-24 CN claimed
CN-102675067-A Method for catalytic synthesis of m-phenoxy benzaldehyde YANGZHOU INST OF CHEMISTRY AND CHEMICAL ENGINEERING NANJING UNIVERSITY 2012-09-19 CN claimed
US-4288386-A Ullmann reaction for the synthesis of diaryl ethers RHONE-POULENC INDUSTRIES (FR) 1981-09-08 US claimed
US-20250188626-A1 CARBON DIOXIDE CAPTURE AND UTILIZATION AS A CLEAN FEEDSTOCK UNIV MICHIGAN TECH (US) 2025-06-12 US disclosed
CN-119285426-A Synthesis method of diaryl acetylene 南京工业大学 2025-01-10 CN disclosed
WO-2023212597-A1 CARBON DIOXIDE CAPTURE AND UTILIZATION AS A CLEAN FEEDSTOCK MICHIGAN TECHNOLOGICAL UNIVERSITY (US) 2023-11-02 WO disclosed
US-11713335-B2 Aminocoumarin compounds and methods of their use PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-08-01 US disclosed
EP-0348002-A2 Herbicidal acrylonitrile derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-12-27 EP disclosed
US-4314070-A REACTING ALKALI PHENATE WITH ALKYL META-HALOBENZOATE, COPPER SULFATE CATALYST RHONE-POULENC INC. (US) 1982-02-02 US disclosed
US-4288386-A Ullmann reaction for the synthesis of diaryl ethers RHONE-POULENC INDUSTRIES (FR) 1981-09-08 US disclosed
US-4242121-A USING A PHENOXYBENZOIC ACID, ITS ESTER OR SALT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-12-30 US disclosed
US-4042603-A SUBSTITUTED DIBENZOFURAN OR 9-FLUORENONE FROM A DIPHENYL ETHER OR BENZOPHENONE UBE INDUSTRIES, LTD. (JA) 1977-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11713335-B2 Aminocoumarin compounds and methods of their use AAAS, PROC, AADAC AKR1C3 2324/4885HDAC8 2434/4885TSHR 4863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.