Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FURIN | P09958 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14314265 | 0.82 | RAB9A (0.40) | MAPK1HTTRAB9AL3MBTL1LMNA | |
| SCHEMBL22964316 | 0.78 | FFAR1 (0.50) | RAB9A | |
| SCHEMBL5532468 | 0.78 | TP53 (0.53) | MAPK1HTTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL13349912 | 0.77 | MAOB (0.50) | — | |
| SCHEMBL14294428 | 0.77 | ABCG2 (0.44) | MAPK1HTTRAB9AL3MBTL1KMT2A | |
| SCHEMBL22964310 | 0.76 | TLR4 (0.49) | SMN1; SMN2TSHR | |
| SCHEMBL3021740 | 0.76 | SMN1; SMN2 (0.39) | MAPK1HTTLMNASMN1; SMN2KMT2A | |
| SCHEMBL23838435 | 0.74 | MAOB (0.57) | KDM4E | |
| SCHEMBL10245926 | 0.74 | MAPT (0.43) | HTTL3MBTL1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12002205 | 0.74 | LMNA (0.60) | MAPK1HTTLMNAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971606-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-04-24 | — | — | EP | disclosed |