Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019786 | 0.90 | SCN9A (0.43) | SMN1; SMN2STIM1ORAI1MAPTKMT2A | |
| SCHEMBL14881583 | 0.88 | STIM1 (0.49) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL14887335 | 0.84 | BACE1 (0.42) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL16019781 | 0.84 | KDM4E (0.58) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL16017260 | 0.82 | PTGS2 (0.44) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL16019817 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL16019778 | 0.82 | GRM1 (0.49) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16017213 | 0.80 | GRM1 (0.48) | SMN1; SMN2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL14881328 | 0.80 | STIM1 (0.62) | SMN1; SMN2STIM1ORAI1ORAI2MAPT | |
| SCHEMBL14887576 | 0.80 | SCN10A (0.44) | STIM1ORAI1ORAI2MAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |