Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887339 | 0.90 | BACE1 (0.44) | BACE1STIM1ORAI1BACE2KDM4E | |
| SCHEMBL16019798 | 0.88 | DGAT1 (0.46) | STIM1ORAI1ORAI2SMOIL2 | |
| SCHEMBL14885575 | 0.88 | STIM1 (0.49) | BACE1STIM1ORAI1ORAI2KDM4E | |
| SCHEMBL16017234 | 0.87 | HSD17B10 (0.50) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL14887346 | 0.84 | SMN1; SMN2 (0.44) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16019781 | 0.84 | KDM4E (0.58) | STIM1ORAI1ORAI2KDM4ENPC1 | |
| SCHEMBL16019776 | 0.82 | ALDH1A1 (0.56) | STIM1ORAI1ORAI2KDM4ENPC1 | |
| SCHEMBL16019778 | 0.82 | GRM1 (0.49) | STIM1ORAI1ORAI2KDM4ENPC1 | |
| SCHEMBL16017213 | 0.80 | GRM1 (0.48) | KDM4EGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14885577 | 0.80 | STIM1 (0.62) | BACE1STIM1ORAI1ORAI2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | BACE1 677/4885STIM1 17/4885ORAI1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.