Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.44 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887767 | 0.90 | NAMPT (0.46) | GRM1GRM4NAMPTSTIM1ORAI1 | |
| SCHEMBL16020544 | 0.89 | STIM1 (0.50) | GRM1GRM4NAMPTSTIM1ORAI1 | |
| SCHEMBL16019781 | 0.84 | KDM4E (0.58) | GRM1GRM4NAMPTSTIM1ORAI1 | |
| SCHEMBL14887335 | 0.82 | BACE1 (0.42) | STIM1ORAI1ORAI2KDM4ENPC1 | |
| SCHEMBL14887346 | 0.82 | SMN1; SMN2 (0.44) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL14885640 | 0.81 | STIM1 (0.64) | GRM1GRM4NAMPTSTIM1ORAI1 | |
| SCHEMBL16019798 | 0.81 | DGAT1 (0.46) | STIM1ORAI1ORAI2 | |
| SCHEMBL16019776 | 0.80 | ALDH1A1 (0.56) | STIM1ORAI1ORAI2KDM4ENPC1 | |
| SCHEMBL16017234 | 0.78 | HSD17B10 (0.50) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16020546 | 0.78 | STIM1 (0.52) | GRM1GRM4NAMPTSTIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | GRM1 1425/4885GRM4 1253/4885NAMPT 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.