Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 2/20 | 0.35 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017235 | 0.92 | RAB9A (0.46) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL16018173 | 0.80 | STIM1 (0.49) | RAB9ANPC1KDM4ESCN9ASTIM1 | |
| SCHEMBL16019820 | 0.79 | KDM4E (0.54) | RAB9ANPC1KDM4EMAPTLMNA | |
| SCHEMBL14887339 | 0.79 | BACE1 (0.44) | KDM4ESMN1; SMN2SCN9ASTIM1ORAI1 | |
| SCHEMBL16019786 | 0.79 | SCN9A (0.43) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL14887767 | 0.79 | NAMPT (0.46) | SCN9ASTIM1ORAI1POLQ | |
| SCHEMBL16009312 | 0.78 | ALDH1A1 (0.46) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL16017216 | 0.78 | STIM1 (0.40) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL14881396 | 0.78 | STIM1 (0.51) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL14887348 | 0.77 | SCN9A (0.43) | RAB9ANPC1KDM4ESCN9ASTIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |