Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 4/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.46 |
| ▸ | MERTK | Q12866 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312672 | 0.93 | TYRO3 (0.53) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5077750 | 0.93 | ACVRL1 (0.47) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14327124 | 0.92 | TYRO3 (0.55) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14313281 | 0.91 | TYRO3 (0.48) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5153730 | 0.90 | ACVRL1 (0.44) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5141187 | 0.90 | TYRO3 (0.47) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5081049 | 0.89 | ACVRL1 (0.44) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL5074948 | 0.88 | ACVRL1 (0.47) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14312522 | 0.87 | TYRO3 (0.52) | ACVRL1TYRO3MERTKAXL | |
| SCHEMBL14313054 | 0.87 | TYRO3 (0.53) | ACVRL1TYRO3MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431695-B2 | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-30 | — | — | US | disclosed |
| US-20110294776-A1 | Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases | BAYER HEALTHCARE AG (DE) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294776-A1 | Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases | IGF1R, FGFR1, IGFBP1 | ACVRL1 336/4885TYRO3 345/4885MERTK 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.