Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.37 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118063 | 0.88 | NAMPT (0.43) | ENPP2EPHX2MGLLLRRK2LMNA | |
| SCHEMBL15996442 | 0.88 | NAMPT (0.43) | ENPP2EPHX2MGLLLRRK2LMNA | |
| SCHEMBL14889464 | 0.87 | CCR3 (0.38) | ENPP2EPHX2CCR3 | |
| SCHEMBL118734 | 0.80 | ENPP2 (0.61) | ENPP2ATXN2 | |
| SCHEMBL118415 | 0.80 | ENPP2 (0.61) | ENPP2ATXN2 | |
| SCHEMBL14889527 | 0.78 | L3MBTL3 (0.49) | L3MBTL3L3MBTL1TP53BP1MBTD1L3MBTL4 | |
| SCHEMBL14889467 | 0.78 | ENPP2 (0.52) | ENPP2LRRK2LMNAL3MBTL3L3MBTL1 | |
| SCHEMBL118338 | 0.78 | ENPP2 (0.52) | ENPP2CCR3LRRK2L3MBTL3L3MBTL1 | |
| SCHEMBL118378 | 0.78 | ENPP2 (0.52) | ENPP2LRRK2LMNAL3MBTL3L3MBTL1 | |
| SCHEMBL14889466 | 0.78 | L3MBTL1 (0.41) | ENPP2CCR3HRH1LRRK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-B1 | Piperidine and piperazine derivatives as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2013-05-01 | — | — | EP | claimed |