Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.60 |
| ▸ | SCN1A | P35498 | 4/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14894050 | 0.85 | SCN9A (0.82) | SCN9ASCN1ASCN8APKMALDH1A1 | |
| SCHEMBL14894227 | 0.84 | SCN9A (0.53) | SCN9ASCN1ASCN8ASCN5A | |
| SCHEMBL7538875 | 0.79 | MEN1 (0.65) | SCN9APKMALDH1A1L3MBTL1TSHR | |
| SCHEMBL7541439 | 0.79 | PKM (0.58) | SCN9APKMALDH1A1L3MBTL1TSHR | |
| SCHEMBL14895703 | 0.77 | SCN9A (0.74) | SCN9ASCN1ASCN8APKMSCN3A | |
| SCHEMBL14893600 | 0.77 | SCN9A (0.74) | SCN9ASCN1ASCN8APKMSCN3A | |
| SCHEMBL14893660 | 0.76 | ALDH1A1 (0.64) | SCN9APKMALDH1A1L3MBTL1TSHR | |
| SCHEMBL14896039 | 0.76 | SCN9A (0.56) | SCN9ASCN1ASCN8APKMSCN3A | |
| SCHEMBL20597275 | 0.76 | SCN9A (0.56) | SCN9ASCN1ASCN8APKMSCN3A | |
| SCHEMBL17527278 | 0.75 | SCN9A (0.45) | SCN9ASCN1ASCN8APKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2770995-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | Merck Sharp & Dohme Corp. (US) | 2014-09-03 | — | — | EP | claimed |
| WO-2013063459-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | claimed |
| EP-2770995-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | Merck Sharp & Dohme Corp. (US) | 2014-09-03 | — | — | EP | disclosed |
| WO-2013063459-A1 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |