Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537163 | 0.90 | SCN9A (0.63) | PKMALDH1A1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL7538875 | 0.86 | MEN1 (0.65) | PKMALDH1A1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL7541039 | 0.80 | PKM (0.75) | PKMALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL14893660 | 0.79 | ALDH1A1 (0.64) | PKMALDH1A1L3MBTL1MAPK1TP53 | |
| SCHEMBL14893602 | 0.79 | SCN9A (0.60) | PKMALDH1A1L3MBTL1MAPK1TP53 | |
| SCHEMBL14894050 | 0.79 | SCN9A (0.82) | PKMALDH1A1L3MBTL1MAPK1TP53 | |
| SCHEMBL7543191 | 0.76 | PKM (0.65) | PKMALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL7537416 | 0.75 | MEN1 (0.64) | PKMALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL7505784 | 0.74 | PKM (1.00) | PKMALDH1A1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL14893887 | 0.74 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170007608-A1 | ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE | AGIOS PHARMACEUTICALS INC (US) | 2017-01-12 | — | — | US | disclosed |
| EP-2427441-B1 | PKM2 ACTIVATORS FOR USE IN THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |
| US-20140249150-A1 | ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE | AGIOS PHARMACEUTICALS, INC (US) | 2014-09-04 | — | — | US | disclosed |
| US-8501953-B2 | PKM2 modulators for use in the treatment of cancer | AGIOS PHARMACEUTICALS, INC (US) | 2013-08-06 | — | — | US | disclosed |
| WO-2013056153-A1 | ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE | KUNG CHARLES (US) | 2013-04-18 | — | — | WO | disclosed |
| US-20120122849-A1 | PKM2 MODULATORS FOR USE IN THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS, INC. | 2012-05-17 | — | — | US | disclosed |
| WO-2010129596-A1 | PMK2 MODULATORS FOR USE IN THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122849-A1 | PKM2 MODULATORS FOR USE IN THE TREATMENT OF CANCER | PDK2, PDK1, PDK3 | PKM 5/4885ALDH1A1 1326/4885L3MBTL1 1733/4885 |
| US-20140249150-A1 | ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE | PDK1, PC, PDK2 | PKM 11/4885ALDH1A1 1390/4885L3MBTL1 1302/4885 |
| US-20170007608-A1 | ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE | PDK1, PC, PDK2 | PKM 11/4885ALDH1A1 1390/4885L3MBTL1 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.